MOTS-c: A Research Overview

MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a member of a class of mitochondrial-derived peptides, short peptides encoded within mitochondrial DNA rather than the nuclear genome. Since its description in the research literature, MOTS-c has been studied as a tool compound for examining mitochondrial signaling, under experimental conditions.

Origin and structure

MOTS-c is encoded within the mitochondrial 12S ribosomal RNA region. This unusual origin is part of why it has attracted research interest: it is one of several peptides that illustrate the coding capacity of the mitochondrial genome.

Pathways studied in preclinical literature

In published in-vitro and animal-model research, MOTS-c has been investigated in relation to mitochondrial signaling and cellular metabolic-regulation pathways. These studies are conducted in cell-culture and animal models under defined experimental conditions and describe areas of ongoing scientific investigation.

As a research material

MOTS-c is supplied as a lyophilized peptide for laboratory study of its molecular and signaling characteristics. As with any research peptide, identity and purity are verified analytically, see our guide on reading a Certificate of Analysis, before use in a protocol.

This overview is provided for educational purposes describing areas of scientific investigation and is not a claim of any effect in humans. MOTS-c offered here is intended for laboratory and research use only and is not for human consumption.